2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W587827
    Thiamine triphosphoric acid ester 3475-65-8 98%
    Thiamine triphosphoric acid ester (Thiamine triphosphate) is a neuroactive compound and a triphosphate derivative of vitamin thiamine. Thiamine triphosphoric acid ester exists in microorganisms, animal organs and plants. In E. coli, Thiamine triphosphoric acid ester is transiently produced under amino acid deficiency, while in mammalian cells, it is continuously produced at a low rate. Thiamine triphosphoric acid ester can be synthesized by two distinct enzymes (cytosolic AK1 and FoF1-ATP synthase in brain mitochondria). Thiamine triphosphoric acid ester plays a fundamental role in cellular metabolism or cellular signal transduction.
    Thiamine triphosphoric acid ester
  • HY-W615699
    2-Formylaminobenzaldehyde 25559-38-0 98%
    2-Formylaminobenzaldehyde (2-Formylphenylformamide) is a nucleoside metabolite.
    2-Formylaminobenzaldehyde
  • HY-W653885
    rac 3,4-Dihydroxymandelic Acid-d3 98%
    rac 3,4-Dihydroxymandelic Acid-d3 is deuterium labeled 3,4-Dihydroxymandelic acid. 3,4-Dihydroxymandelic acid is a metabolite of norepinephrine.
    rac 3,4-Dihydroxymandelic Acid-d3
  • HY-W654074
    1,2-Dilauroyl-3-chloropropanediol-d5 98%
    1,2-Dilauroyl-3-chloropropanediol-d5 (1,1′-[1-(Chloromethyl)-1,2-ethanediyl] didodecanoate-d5) is the deuterium labeled 1,2-Dilauroyl-3-chloropropanediol (HY-W587507). 1,2-Dilauroyl-3-chloropropanediol (1,1′-[1-(Chloromethyl)-1,2-ethanediyl] didodecanoate) is an ester product.
    1,2-Dilauroyl-3-chloropropanediol-d5
  • HY-W654215
    Homovanillic acid sulfate sodium 98%
    Homovanillic acid sulfate (sodium) is a phenol that can be found in olive oil and a dopamine metabolite. Homovanillic acid sulfate (sodium) increases in response to acute renal injury in vivo. Homovanillic acid sulfate (sodium) can be used as a biomarker for early detection of kidney disease.
    Homovanillic acid sulfate sodium
  • HY-W654252
    Linoleoyl Carnitine (N-methyl-d3) 98%
    Linoleoyl Carnitine (N-methyl-d3) is the deuterium labeled Linoleyl carnitine (HY-113256). Linoleyl carnitine is an acylcarnitine used to study long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and fatty acid oxidation disorders in fibroblasts.
    Linoleoyl Carnitine (N-methyl-d3)
  • HY-W665208
    Zapotin 14813-19-5 98%
    Zapotin is a member of the polymethoxyflavones, which are natural polyphenols from the group of flavonoid. Zapotin exhibits antidepressant, anticancer, antifungal, and antioxidant activity. Zapotin is a chemopreventive and chemotherapeutic agent. Zapotin can result in a reduction of large aberrant crypt foci in CF-1 mouse model. Zapotin inhibits autophagosome formation. Zapotin has inhibitory activity in mouse mammary organ culture with an IC50 of 50 µg/mL.
    Zapotin
  • HY-W673613
    ADX68692 1067191-08-5 98%
    ADX68692 is an orally active negative allosteric modulators of follicle-stimulating hormone receptor with a log IC50 of -5.71. ADX68692 can inhibit hCG-induced cAMP production and s ß-arrestin 2 recruitment in HEK293 cells. ADX68692 exhibits a partial effect in both mLTC-1 and primary rat Leydig cells. ADX68692 inhibits FSHR-promoted cAMP, progesterone and estradiol production. ADX68692 can reduce the number of oocytes recovered from the ampullae.
    ADX68692
  • HY-W674286
    N2-Succinyl-L-arginine 2478-02-6 98%
    N2-Succinyl-L-arginine is a nucleoside metabolite.
    N2-Succinyl-L-arginine
  • HY-W685358
    D-Tetramethrin 1166-46-7 98%
    D-Tetramethrin is a type I synthetic pyrethroid insecticide and hepatotoxicity inducer. D-Tetramethrin induces oxidative stress in the liver of zebrafish. D-Tetramethrin induces Apoptosis and inflammatory responses. D-Tetramethrin causes severe liver damage in zebrafish. D-Tetramethrin can be used in studies related to hepatotoxicity.
    D-Tetramethrin
  • HY-W698271
    Ferrous lactate trihydrate 6047-24-1 98%
    Ferrous lactate trihydrate is a type of iron supplement. Ferrous lactate trihydrate promotes the production of hemoglobin by providing available ferrous ions (Fe²⁺). Ferrous lactate trihydrate can be used in studies on iron-deficiency anemia.
    Ferrous lactate trihydrate
  • HY-W698694
    N4-Acetylsulfamerazine-d4 1189896-03-4 98%
    N4-Acetylsulfamerazine-d4 (Acetylsulfamerazine-d4; Sulfamelazine-d4) is the deuterium labeled N4-Acetylsulfamerazine (HY-W031230). N4-Acetylsulfamerazine is a sulfonamides derivative.
    N4-Acetylsulfamerazine-d4
  • HY-W698964
    2′-Hydroxy-5′-nitrohexadecanamide 60301-87-3 98%
    2′-Hydroxy-5′-nitrohexadecanamide is a lysosomal hydrolase inhibitor and is a lipid containing pentadecanoic acid and a terminal nitrophenol in its structure. 2′-Hydroxy-5′-nitrohexadecanamide can cause intracellular lipid accumulation by inhibiting lysosomal hydrolase activity. Additionally, 2′-Hydroxy-5′-nitrohexadecanamide can be used to synthesize chromogenic substrates for measuring sphingolipase activity.
    2′-Hydroxy-5′-nitrohexadecanamide
  • HY-W699369
    1-Palmitoyl-3-O-benzyl-rac-glycerol 1487-51-0 98%
    1-Palmitoyl-3-O-benzyl-rac-glycerol is a diacylglycerol that contains Palmitic acid (HY-N0830) and Oleic acid (HY-N1446).
    1-Palmitoyl-3-O-benzyl-rac-glycerol
  • HY-W699866
    Gemfibrozil 1-O-β-glucuronide-d6 1703747-47-0 98%
    Gemfibrozil 1-O-β-glucuronide-d6 is the deuterium labeled Gemfibrozil 1-O-β-glucuronide (HY-129993). Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM.
    Gemfibrozil 1-O-β-glucuronide-d6
  • HY-W699907
    Pantoprazole sulfide-d8 1189977-42-1 98%
    Pantoprazole sulfide-d8 is the deuterium labeled Pantoprazole sulfide (HY-W016033). Pantoprazole sulfide is a metabolite of Pantoprazole (HY-17507), which is a proton-pump inhibitor.
    Pantoprazole sulfide-d8
  • HY-W700354
    (S)-(-)-Felodipine 105618-03-9 98%
    (S)-(-)-Felodipine is a S-enantiomer of Felodipine. (S)-(-)-Felodipine is an antihypertensive agent. Felodipine is a 1,4-dihydropyridine derivative and a vasoselective calcium antagonist. Felodipine can prevent the activation of the vascular effector cells and interfere with the contractile process in vitro. Felodipine lowers mean arterial blood pressure by 20% in dog model. (S)-(-)-Felodipine shows high metabolic rate in rat and dog liver microsomes.
    (S)-(-)-Felodipine
  • HY-W700788
    Isobutyryl-L-carnitine chloride-d6 98%
    Isobutyryl-L-carnitine chloride-d6 is the deuterium labeled Isobutyryl-L-carnitine chloride (HY-113165A). Isobutyryl-L-carnitine chloride is a product of the acyl-CoA dehydrogenases.
    Isobutyryl-L-carnitine chloride-d6
  • HY-W701772
    2-Oleoylglycerol-d5 946524-37-4 98%
    2-Oleoylglycerol-d5 (2-OG-d5) is the deuterium labeled 2-Oleoylglycerol (HY-W011121). 2-Oleoylglycerol (2-OG) is a lipid found in the diet. It is a GPR119 agonist, with an EC50 value of 2.5 μM in activating hGPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol enhances the inflammatory response of macrophages and promotes fibrosis by activating the GPR119/TAK1/NF-κB/TGF-β1 signaling pathway. It also stimulates glucagon-like peptide 1 (GLP-1) secretion in vivo. 2-Oleoylglycerol is expected to be used in the research of non-alcoholic steatohepatitis (NASH) .
    2-Oleoylglycerol-d5
  • HY-W702907
    DM-4103 1346599-56-1 98%
    DM-4103 is a major metabolite of Tolvaptan (HY-17000) that is metabolized primarily by the CYP3A4 enzyme in the liver. DM-4103 inhibits the ability of human liver transporters NTCP, BSEP, MRP2, MRP3, MRP4 (IC50 values are 16.3, 4.15, 51.0, 44.6, 4.26 μM, respectively) and bile acid transport in SCHH cells. DM-4103 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD).
    DM-4103
Cat. No. Product Name / Synonyms Application Reactivity